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24 Nevertheless, in most species, the majority of L cells are located in the distal gut, and the quantitative contributions of proximal gut L cells to the control of glucose homeostasis and circulating levels of GLP-1 throughout the day remains questionable

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Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-nave patients with type 2 diabetes (SUSTAIN 4): a randomized, open-label, parallel-group, multicentre, multinational, phase 3a trial

Patients with heart failure may also require long-term treatment to maintain cardiac function and prevent disease progression

Effectiveness depends as much on consistent adherence as on bioavailability