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Individuals with minimal weight to lose (BMI under 27 kg/m without comorbidities) do not meet clinical criteria for pharmacological weight loss treatment

Some investigators have characterized Alzheimer's disease as "type 3 diabetes" due to observed insulin resistance in the brain, though this terminology remains controversial and is not universally accepted

However, increasing data suggest that the pronounced weight loss with GLP-1 RAs may be accompanied by a decrease in SM mass

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