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Breaking this cycle is one of the goals of weight loss therapy

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If you have never lost more than 2 to 3 percent of your body weight despite being on an adequate dose for 3 or more months with good adherence, you may be a non-responder and should discuss alternatives with your provider

Interpretation: Once-weekly semaglutide was superior to sitagliptin at improving glycaemic control and reducing bodyweight in participants with type 2 diabetes on metformin, thiazolidinediones, or both, and had a similar safety profile to that of other GLP-1 receptor agonists

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