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Gradual increments: After four weeks, its typical to experience a dose escalation

Diarrhea is usually short lived and manageable, and with the small changes listed above it rarely becomes a long-term problem

The first four weeks at 0.25 mg produce the mildest side effects

Highlights of Prescribing Information: Wegovy (semaglutide) injection, for subcutaneous use

GLP-1 Side Effects at a Glance Nausea & vomiting Constipation Diarrhea Reflux & sulfur burps Loss of muscle and lean mass Skin, hair, and nail changes Fatigue, depression, and the blahs Dehydration Less Common but Serious Side Effects Pancreatitis and pancreatic cancer Gallstones & gallbladder disease Thyroid cancer Acute kidney injury Retinopathy, macular degeneration, and nonarteritic anterior ischemic optic neuropathy (NAION) Common GLP-1 Side Effects and How to Manage Them Most side effects show up early, often within the first few days of beginning GLP-1 treatment