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In contrast to other proteins that do not engage FcRn, the two ligands are prevented from progressing to the lysosomes for degradation by binding to the receptor in early sorting endosomes 41,43,47,49,50
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Lastly, in a nonhuman primate model of AD, liraglutide provides partial protection, reducing AD-related insulin receptor, synaptic, and tau pathology in specific brain regions [82]
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