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Additionally, the safety of these drugs is put into perspective with that of other drugs currently approved for the treatment of PLWO

The proposed mechanism: the leucine substitution increases hydrophobicity, potentially stabilizing the signal peptide and improving receptor trafficking to the cell surface meaning more receptor, more drug response

Methods Data were obtained from trials with subcutaneous and intravenous administration of semaglutide that utilised frequent PK sampling and included a total of 353 subjects with 10,573 concentration values

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