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Description
During the 36-week, open-label treatment period, study patients achieved mean weight loss of 21%, or approximately 22.5kg/50 pounds
A 2.5 mg dose of tirzepatide and a 0.25 mg dose of semaglutide are both "starting doses" that serve the same purpose, tolerance building, but the actual pharmacology behind each number is unique

If the pen is not used within 21 days of being at room temperature, it should be discarded even if the printed expiration date has not passed
However, certain factors increase aspiration risk and may warrant additional precautions: Higher-risk features include : Recent initiation or dose escalation of Mounjaro Active gastrointestinal symptoms (nausea, vomiting, reflux) Known gastroparesis or autonomic neuropathy Higher maintenance doses (10 mg or 15 mg weekly) Concurrent opioid use or chronic kidney disease Procedures with higher aspiration risk For higher-risk patients , management options may include: A 24-hour clear liquid diet before surgery Point-of-care gastric ultrasound assessment if available Managing as a 'full stomach' with appropriate anaesthetic technique In some cases, considering postponement if in active dose escalation with significant symptoms For emergency or urgent surgery , stopping Mounjaro in advance is not possible

Molecular Metabolism (2018) 12
