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To this end, high-fat-diet (HFD) feeding in mice has been shown to induce beta-cell-like changes in the electrical profile of a subset of alpha-cells (73)

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In response to the FDAs complete response letter (CRL), announced Friday by Mesoblast, the New Yorkbased biopharma will conduct a targeted, controlled study in the highest-risk adults with the greatest mortality. Mesoblast noted that the adult study is in line with its overall commercial strategy, which involves a progression from pediatric to adult SR-aGVHD indications