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Patch pipettes, prepared with a micropipette puller (Narishige, Tokyo, Japan), had resistances of 45 M for whole-cell recordings and 68 M for cell-attached recordings
Consistent with this, glucagon-stimulation of insulin secretion is decreased in islets isolated from -cell-specific GLP-1R KO mice [173]
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10.1152/ajpendo.1999.277.5.E784 [DOI] [PubMed] [Google Scholar] Berthoud, H
6,14 Furthermore, GLP-1 signaling indirectly enhances and restores the insulin signaling pathway in neurons, leading to a reduction in the phosphorylation of insulin receptor substrates and the burden caused by monomeric -synuclein
