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Statistical analysis The comparison of risk among the cohorts was performed using Cox proportional hazards regression analysis, focusing on the incidence at 1, 3, and 5 years following the prescription date of the drugs

Additional genetic markers affecting medication response include variants in the FTO and MC4R genes, which regulate appetite signaling and metabolic rate

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10.1158/0008-5472.CAN-10-1040 [DOI] [PMC free article] [PubMed] [Google Scholar] Tan B

[Accessed on 11 June 2026] Lillys oral GLP-1, orforglipron, superior to oral semaglutide in head-to-head trial (2025/2026)