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The pathophysiology is unclear, but risk factors are thought to be the same as the type 1 diabetic patients who rapidly improved A1c in the Diabetes Control and Complications Trial: long duration of diabetes mellitus, long duration of poor glycemic control, worse baseline level of DR prior to treatment and magnitude of reduction in A1c after treatment

Your side effect history : If youve tried semaglutide and had intolerable nausea, tirzepatide might be different (or might be worse)

Macrophages in tissue repair, regeneration, and fibrosis

All the cardiometabolic parameters improved as well

Injection site reactions occur in 5 to 10% of people