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Simultaneously, these agents suppress glucagon secretion from pancreatic alpha cells, thereby reducing hepatic glucose production when it is not needed

Lancet 377:13411352 Allison DB, Gadde KM, Garvey WT, Peterson CA, Schwiers ML, Najarian T, Tam PY, Troupin B, Day WW (2012) Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP)

Importantly, even when calorie restriction is not enforced, the MD does not promote weight gain, suggesting a natural satiety-enhancing and metabolically favourable composition [116]

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Hormone and fertility benefits In 2023, the American Society for Reproductive Medicine (ASRM) updated its guidance on treating PCOS to include a note about the potential of GLP-1s for weight management and improved fertility