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To compensate for this insulin resistance, the pancreas produces more insulin, leading to higher-than-normal insulin levels in the bloodstream

Interestingly, the SURPASS-2 trial found that patients on tirzepatide 5 mg experienced less nausea (17.4%) and vomiting (5.7%) compared to those on semaglutide 1 mg, who reported 19.2% nausea and 8.1% vomiting, despite tirzepatide leading to greater weight loss

Statements Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

What Retatrutide is Retatrutide is an investigational once-weekly triple hormone receptor agonist being developed by Eli Lilly