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The effects of overexpressing FXR were recovered by limiting miR-33 expression, demonstrating that FXR decreased GLP-1 secretion via boosting miR-33 expression and, by extension, GCG and CREB1 expression

FlexTouch and KwikPen delivery systems minimize injection errors critical for GLP-1 therapies where dose escalation spanning 16 to 20 weeks requires milligram-level titration

doi:10.1136/postgradmedj-2019-137186 Kreymann B, Williams G, Ghatei MA, Bloom SR

However, these medications may be covered under Medicare for type 2 diabetes, cardiovascular risk reduction (Wegovy), or obstructive sleep apnea (Zepbound)

Exenatide, a synthetic variant of exendin-4, incorporates strategic modifications that substitute asparagine (Asn) at the C-terminal with aspartic acid (Asp) and swap alanine (Ala) at the 8 th position with glycine (Gly)