glp 1 drugs moa Glucagon-like peptide receptor agonists: cardiovascular benefits and mechanisms of action glp 1 inhibitors moa GLP1-GIP

Here, GLP-1RAs are one exciting option [28]

A study in female patients with obesity who were prescribed a 925 kcal diet for 16 weeks followed by a 12001500 kcal diet for 32 weeks showed 11% weight loss in the first 2 months with reductions in triglycerides and total cholesterol by 22.7% and 15.7% respectively [29]

Due to the current shortage of these highly effective medications, compounded versions are becoming more common

Propensity score adjustment was applied to account for baseline differences

This approach is not intended to diminish enthusiasm for underexplored peptide systems, but rather to strengthen the case for their systematic and responsible re-evaluation using modern tools