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Research on orforglipron Clinical studies suggest that orforglipron can significantly improve both weight loss and blood sugar control in adults with obesity or type 2 diabetes

However, using tirzepatide when hypothyroidism is present requires careful baseline thyroid assessment and ongoing monitoring, because GLP-1 medications can theoretically influence thyroid function or mask thyroid-related symptoms through appetite suppression

However, 7 cross sectional studies examining acute effects of the GLP-1-based therapies 37,38,39,40,41,42,43 found a significant increase in % FMD following GLP-1-based interventions (mean difference in the changes from baseline: 2.58 [1.68, 3.53] %

As for GLP-1 side effects related to vision, a study of more than 16,000 patients published in JAMA Ophthalmology found a higher risk of a rare eye condition called NAION in semaglutide users