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Notably, the hypothalamicpituitaryadrenal axis is impaired in Covid-19 patients, as reflected by low ACTH and cortisol levels

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16 Where did the concern for DR progression come from

Several studies describe a bidirectional association between IR, HPA axis dysfunction, and depression, particularly among patients with type 2 diabetes [5,9]

Interestingly, when these experiments were widened to include other test agonists, a similar pattern was observed to that of chronic insulin secretion in Fig
