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A person who loses 50 pounds of mostly fat while retaining muscle has achieved something profoundly different from someone who loses 50 pounds of mixed fat and muscle

Eli Lilly is not pursuing oral tirzepatide

The approval would open "up the opportunity for many more people to benefit from tirzepatide," Eli Lilly CEO David Ricks said Thursday on CNBC's "Squawk Box." He added that the drug sets a "new bar for weight loss and people with diabetes." The data come as companies try to capitalize on increased consumer demand for weight loss treatments

Protein supplementation combined with resistance training leads to greater preservation of lean mass and strength than training alone. Key point: With adequate protein intake and resistance training, patients can maintainand sometimes increasestrength during GLP-1 therapy despite overall weight loss. Recovery and micronutrients Adequate sleep, hydration, and correction of deficiencies (including vitamin D when present) further support muscle function and recovery. Bottom Line: GLP-1 Medications Improve Body Composition Not Muscle Wasting Semaglutide and tirzepatide do not inherently cause muscle wasting. Most weight lost is fat , and body composition improves. Muscle wasting is primarily a risk of undernutrition , not GLP-1 therapy itself. Protein + resistance training is the most effective strategy to preserve muscle. At Potere Health MD, GLP-1 and GIP therapy is paired with evidence-based nutrition and strength guidance so weight loss is healthier, stronger, and more sustainable