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Berberine is available in the United States as a dietary supplement, not as an FDA-approved medication

Several agents also carry evidence for heart benefits, elevating them beyond strictly glycemic drugs

Higher doses may accelerate weight loss but can also increase certain side effects, such as hair loss

There is no evidence that stimulants reduce the efficacy of semaglutide or tirzepatide for weight loss or glucose control

Need for Affordability Physicians emphasize the necessity for drastic price reductions, inclusion in public health schemes, or development of affordable biosimilars/generics for these drugs to have a real public health impact in India