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Measurement of undercarboxylated osteocalcin is technically challenging, with inter-assay variability and confounding by vitamin K status complicating interpretation

Now, the other thing that does happen in perimenopause, menopause

It also indicates that analyzing mixed-age groups may reduce the chances of detecting potential differences, if such for example exist exclusively in premenopausal women

We aimed to contrast addon therapy, adherence, and changes in biomarkers, 1 year after treatment initiation with GLP1 RA or metformin

The EXSCEL trial did not find any significant difference in the primary outcome between treatment with the long-acting GLP-1RA exenatide once weekly and placebo