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Pfeffer MA, Claggett B, Diaz R et al

participants received at least two doses of exclusive GLP-1 receptor agonist therapy, metformin or insulin after a diagnosis of type 2 diabetes

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A reasonable starting framework, based on extrapolation from GLP-1 nasal delivery literature, might look like this: Conservative approach: Begin with 0.5-1mg per nasal actuation, administered once daily
