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INTRODUCTION The incretin hormones secreted by L cells in the ileum and colon are GLP-1 receptor agonists (RAs) [3]

Those are remarkable response rates

Older adults are at higher risk of muscle wasting (sarcopenia)

What to Know About the BALANCE Model for GLP-1s in Medicare and Medicaid and the Medicare GLP-1 Bridge Editorial Note This brief was updated on May 11, 2026 to reflect changes in the Trump administrations plans for implementation of the BALANCE Model in Medicare and an extension of the Medicare GLP-1 Bridge program through 2027

Missing doses or titrating on your own can cause either more side effects or fewer benefits