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NICE has published guidance on pharmacological interventions for weight management, including NICE guideline CG189 (Obesity: identification, assessment and management) and a technology appraisal supporting the use of semaglutide (Wegovy) for adults with a BMI of 35 kg/m or above (or 3034.9 kg/m in certain circumstances) alongside a specialist weight management service

Those who started at 4mg saw faster initial appetite effects but also experienced higher rates of nausea and other gastrointestinal side effects

Most patients notice subjective improvements energy, reduced abdominal firmness within 48 weeks

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This is due to expanding cardiovascular outcome data