glp-1 agonists and pancreatitis The pancreatic extrapancreatic effect of GLP-1. GLP-1, glucagon GLP-1–Based Therapies: The Dilemma of

Longacting preparations of exenatide

A GLP-1 receptor agonist medication may help patients with psoriasis.[ref] Related article: T Cell Exhaustion Asthma symptoms decrease: Asthma exacerbations also decreased in patients on GLP-1 receptor agonist medications.[ref] ( Related article : Asthma genes) Dementia and Alzheimers Prevention: In animal studies, infusions of GLP-1 decrease amyloid-beta levels and prevent neuronal cell death.[ref] Dysregulation of glucose entry into the brain is one hallmark of Alzheimers disease, tying together insulin resistance, GLP-1, and dementia.[ref][ref] GLP-1 receptor agonist drugs, such as liraglutide, are being studied for Alzheimers disease.[ref] Studies using data from diabetes patients showed a significant decrease in dementia for those on GLP-1s vs other diabetes medications

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doi: 10.1001/jama.2019.22360 57 JankovicJTanEK

Weight-loss outcome assumptions (15% average reduction in body weight over 12 months) were based on results from the STEP 1 and SURMOUNT 1 clinical trials