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Neal B, Perkovic V, Mahaffey KW, de Zeeuw D, Fulcher G, Erondu N, Shaw W, Law G, Desai M, Matthews DR, CANVAS Program Collaborative Group

This question has gained attention as GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) become increasingly prescribed for type 2 diabetes and weight management

Semaglutide tiredness is a common complaint among usersespecially in the first few weeks or after a dose increase

Fat metabolism Explored in research on lipolysis and energy expenditure tied to its glucagon-receptor activity, in preclinical and clinical study

J Clin Endocrinol Metab 103(6):22912301