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Recent final draft guidance from NICE (2026a) has recommended semaglutide up to a dose of 2.4 mg subcutaneously once weekly for people without diabetes and: with pre-existing CVD (previous MI, stroke or peripheral vascular disease) and a BMI of 27 kg/m 2 for CV protection (to reduce CV death, non-fatal MI, non-fatal stroke)

Many patients face barriers such as high out-of-pocket costs and limited insurance coverage for these medications, which can hinder adherence and ultimately affect treatment outcomes [62]
Activation of GLP-1 receptors improves endothelial function by enhancing nitric oxide bioavailability and subsequent vasodilation

Apart from these cardiovascular mechanisms, increased BMI independently correlates with mortality risk

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