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A RETROSPECTIVE study conducted by Mass General Brigham researchers has found that taking semaglutide before bariatric surgery does not improve overall weight loss or safety outcomes compared to surgery alone

Canadian researchers interested in this compound must currently access it through research chemical suppliers rather than pharmaceutical channels

Receptor activation engages Gs signalling, raising intracellular cAMP and modulating downstream effects on pancreatic -cells and several extra-pancreatic tissues studied in cellular and rodent models

In a twist, the study found that although there was a small increase in diabetic retinopathy, GLP-1 use appeared to protect against the conditions progression and sight-threatening complications

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