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in others it is reassessed entirely

Despite lower efficacy and tolerability shown by nasally administered PYY agonists in early studies, long-acting subcutaneous PYY receptor agonists such as PYY 1875 are undergoing early-phase clinical trials to evaluate their safety and effectiveness as monotherapy or in combination with GLP-1 receptor agonists for the treatment of obesity

[DOI] [PubMed] [Google Scholar] 64.Bethel M.A., Patel R.A., Merrill P., Lokhnygina Y., Buse J.B., Mentz R.J., Pagidipati N.J., Chan J.C., Gustavson S.M., Iqbal N., et al

23 In clinical trials, treatment-discontinuation rates are around 5% to 10%

This is thought to be a key player in the sexual side effects often experienced by those taking selective serotonin reuptake inhibitors (SSRIs), such as reduced libido and delayed orgasm