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1 Vascular-barrier effects: less blood-brain barrier disruption, a pathway that could affect edema, hemorrhagic transformation risk, or downstream immune-cell entry

21 Several studies suggest that the neuroprotective actions of GLP-1 medicines may also be mediated by improvements in brain insulin resistance and glucose metabolism, in part through restoration of impairments in insulin receptor substrate 1 phosphorylation, 22 effectively re-establishing functional central insulin signaling, although the data linking GLP-1 action to central insulin signaling are limited

Svetlana Mojsov, as a graduate student with Bruce Merrifield at Rockefeller University, developed novel methods of solid phase peptide synthesis that enabled her to synthesize the short peptide hormone glucagon, which protects against hypoglycemia

Saxenda has a multi-dose pen that is used multiple times before you throw it away and requires separate needle purchases