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A significant drug main effect (p=0.001), as well as a trend-level drugtime-point interaction effect (p=0.08) was also detected for GLP-1, suggesting that GLP-1 concentrations were lower under cannabis, compared to the placebo condition

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In four cancer types, the GLP-1 group was less likely to develop stage IV cancer: Lung cancer - 50% risk reduction Breast cancer - 43% risk reduction Liver cancer - 38% risk reduction Colorectal cancer - 31% risk reduction In the other three cancers - prostate, pancreatic and kidney - the GLP-1 group had fewer instances of stage IV disease, but the differences were not statistically significant

Their pleiotropic benefits arise from intricate signalling cascades that regulate appetite, insulin secretion, and energy homeostasis across multiple tissues.

AMPK pathway explained.