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People who have persistent GI side effects at 8mg often make the pragmatic choice to maintain that dose rather than escalate further

Glucagon influences energy balance in order to modulate body weight via facultative thermogenesisincreased heat production primarily in brown adipose tissue (BAT) and skeletal muscle when heat-saving mechanisms such as piloerection cannot maintain body temperature within a physiologic range [86]

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The triple-receptor profile, i.e., the potential simultaneous GLP-1R, GIPR, and GCGR agonism, may distinguish it from all prior compounds in the incretin research class as a preclinical tool