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Hormonal shifts during perimenopause and menopauseparticularly the drop in estrogen, progesterone, and DHEAcreate a cascade of changes in the body: Slower metabolism (especially after age 40) Increased insulin resistance Visceral fat accumulation (around the belly and midsection) Disrupted sleep and cortisol imbalance Loss of lean muscle mass This isnt just about appearance
Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein

These large, complex molecules are inherently unstable and prone to degradation through pathways such as aggregation, deamidation, and oxidation 3

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However, science has historically excluded pregnant women from clinical studies