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The GLP-1 group showed a mean questionnaire score decrease of 4.05 points, compared to just 1.15 points in the behavioural-only group nearly four times the improvement

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Within-subject variability in bioavailability was 137%, which with once-daily dosing and a long half-life translates into 33% within-subject variability in steady-state exposure

Acolo, Tirzepatide este comparat direct cu Semaglutide la pacieni tratai cu metformin i arat o scdere mai mare a HbA1c i o reducere mai pronunat a greutii corporale, ceea ce susine conceptul c activitatea dubl (GIP/GLP-1) poate avea un efect metabolic suplimentar fa de GLP-1 utilizat singur