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Baker and colleagues recently described the de novo design of miniprotein antagonists for several class B GPCRs, including GIPR, using RFdiffusion and metaproteome-derived scaffolds [26]

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Similarly, severe abdominal pain, particularly if localised to the upper abdomen and radiating to the back, requires urgent assessment to exclude pancreatitis, a rare but serious potential adverse effect of GLP-1 receptor agonists identified in the Wegovy SmPC and MHRA safety monitoring