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Alhajahjeh A, Al-Faouri R, Bahmad HF, Bader T, Dobbs RW, Abdulelah AA, et al

While GLP-1 clearly affects appetite centers in the brain, adding GIP agonism might influence different neural circuits related to food reward, energy expenditure, or metabolic regulation

engineered to target fat reduction without influencing blood sugar or insulin levels

This effect is more clear in animal studies, where weight-matched controls are easy to achieve by restricting access to food and any changes in diet are controlled for
