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Is weight loss the primary concern, or are you addressing obesity-related comorbidities such as type 2 diabetes or hypertension

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Studies are currently underway to evaluate these changes on a histologic and molecular level

However, persistent or severe vomiting warrants medical review, as dehydration and electrolyte disturbances can occur, potentially leading to acute kidney injury

Nevertheless, previous studies have relied solely on morphological observation or specific immunohistochemical staining markers to detect these reactive microglia, which were found to cluster in close proximity to pathological hallmarks such as amyloid plaques or -syn deposits in various brain regions of mouse models and human postmortem cases