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19 Another study by Wai and colleagues using a multi-institutional US database found greater risk of progression to PDR and DME in GLP-1RA users compared to SGLT-2I controls after propensity score matching for baseline characteristics

The science behind this is well established

However, the long-term implications of prolonged GLP-1 medication use remain a topic of ongoing research and debate, Thompson says

In this context, multidose devices can help reduce material consumption while maintaining flexibility in treatment regimens

The phase 3 randomized withdrawal trial evaluated the long-term efficacy of tirzepatide for weight maintenance in adults with obesity or overweight