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Patients must also take a trial of phentermine, an older drug chemically related to amphetamines and still widely used for weight loss, before they can be approved for GLP-1s

Long-term PPI use impairs intestinal magnesium absorption, likely through inhibition of TRPM6/7 magnesium transport channels

The second group consisted of people who already had a diagnosed substance use disorder

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According to the websites of these drugs, there are warnings that there may be dose-dependent and treatment duration-dependent risk for C cell tumors at clinically relevant exposures. This has not been studied in humans and, thus far, there are no reports of these findings