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Each increase follows the same pattern: a brief intensification of appetite suppression and possible mild GI side effects, followed by stabilization at a new, more effective baseline

While these symptoms are typically most pronounced during initial treatment and dose increases, they often improve with time as the body adapts

This dual mechanism provides enhanced benefits in blood sugar control and weight reduction compared to GLP-1 agonists alone

Because tirzepatide activates two receptors (GLP-1 and GIP) while semaglutide activates one (GLP-1 only), the shape of this dose-response relationship may differ between the medications

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