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To better understand the drug's effects, investigators analyzed data from the STEP 1, 3, 4, 5, 8 and 9 trials

Importantly, results reinforced its role not only in diabetes management but also in primary prevention for patients with obesity and prediabetes

Circulating levels decline with agefrom ~200 ng/mL at age 20 to ~80 ng/mL by age 60correlating with decreased regenerative capacity

Once you reach effective dose, weight loss continues at 1-2 pounds weekly as long as calorie deficit persists

Supporting this hypothesis, we demonstrate that GLP-1 receptor-mediated targeting of MK-801 effectively avoids other adverse effects associated with MK-801 monotherapy, including hyperthermia and hyperlocomotion