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In summary, the cell-type selective expression of Gcg is regulated through more than a dozen transcription factors that selectively bind to cis-acting elements in the Gcg promoter and enhancer regions, thereby either stimulating or inhibiting Gcg expression

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In order to monitor the intracellular translocation of agonists, as well as GLP-1Rs, we used fluorescently labeled exendin-4, exendin-phe1, and exendin-asp3 conjugates, with fluorescein isothiocyanate (FITC) at position K12, which we previously found useful for labeling GLP-1R 28

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