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Waist circumference reductions averaged 14.6 cm (5.7 inches) at the 10 mg dose and 17.2 cm (6.8 inches) at the 15 mg dose

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Safety and Pregnancy Considerations Spironolactone is not safe for use during pregnancy due to its anti-androgenic effects, which can lead to fetal feminization and congenital abnormalities, particularly in male fetuses (e.g., ambiguous genitalia)

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But for women with PCOS, this can cause a ripple effect and potentially influence estrogen levels (and other hormones) in the process