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Other investigations may include assessment of renal function, blood glucose, and vitamin B12 levels

The vast majority of the cost of diabetes care is related to the development of diabetic vascular complications, with CVD disease contributing 50% of that cost, and two recent studies, LEADER and SUSTAIN-6, have demonstrated that GLP-1 RAs decrease cardiovascular events

N Engl J Med (2021) 385:896907

This finding highlights that while GLP-1RAs represent a promising therapeutic avenue for DDES, further comparative effectiveness research is needed to determine their relative efficacy within the modern antidiabetic armamentarium