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Clinical data from the SUSTAIN trials and regulatory assessments show that: Gastrointestinal symptoms are most common during the early weeks of treatment Symptoms often occur or worsen transiently after each dose increase Most patients experience improvement over time with continued treatment A small percentage of patients discontinue treatment due to persistent gastrointestinal symptoms, with rates varying by dose Individual variation is considerable some patients experience minimal nausea that resolves within days, whilst others may have symptoms lasting several weeks or longer

Some studies have evidenced that hyperinsulinemia may activate the renin-angiotensin system, increase sympathetic nervous system activity and renal sodium retention and, if sustained, all these elements could increase blood pressure (112, 114)

These healthy unsaturated fats help to absorb certain vitamins and stabilize energy throughout the day