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Other important safety considerations include risk of hypoglycaemia when combined with insulin or sulfonylureas, potential gallbladder disease, and the need for monitoring in patients with pre-existing diabetic retinopathy

It is not recommended in patients with a history of thyroid tumors and endocrine neoplasias

Oral semaglutide has 0.4% to 1% bioavailability due to degradation in the stomach and intestines

9 Given their ability to slow gastric emptying, perioperative concerns with the use of GLP-1 RAs pertain to their potential to increase the risk of aspiration as described in multiple case reports, case series, and observational studies10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 (Table 2, Table 3)