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In addition, we observed that the protein expression of PI3K and p-Akt in the TNC gradually increased in the CM model, and inhibiting the PI3K/Akt pathway by repeated administration of the selective antagonist LY294002 relieved NTG-induced basal tactile allodynia

Pharmacologic options like acarbose are reserved for refractory cases

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Kidney and Liver Function The kidneys and liver are the primary organs responsible for filtering and clearing substances from the human body

We started with the dose of 0, 1 mcg (1/100 of the targeted dose) than increased the doses with 30 min intervals