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You may be ready to stop or down-titrate if: Cycles are regular (2635 days) Ovulation is consistent Luteal phase is stable (1014 days) Weight loss is ~510% Metabolic markers have improved At this point, the primary fertility benefit of GLP-1s has likely been achieved

The metabolic benefits of fasting beyond weight loss include improved insulin sensitivity, reduced inflammatory markers, improved lipid profiles, and autophagy induction

Tirzepatide (Mounjaro, Zepbound) targets two pathways (GLP-1 and GIP), producing greater weight loss in head-to-head studiesroughly 20% body weight loss on tirzepatide vs 15% on semaglutide

Semaglutide is indicated for people with obesity (BMI over 30) or overweight with weight-related comorbidities (BMI over 27)

Misleading promotional claims can lead to serious regulatory actions