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Moreover, administration of a liver-targeted TR-selective agonist increases GLP-1 and insulin levels and alleviates hyperglycemia in diet-induced obesity

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When muscle drops too much during weight loss, patients may experience: Reduced strength Lower energy Poorer exercise tolerance Increased frailty risk Greater chance of weight regain Less favorable body shape after weight loss Reduced metabolic flexibility Higher risk of functional decline with aging This is one reason the term skinny fat has become common in wellness conversations