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Another possibility is that GIP reduces the metabolic adaptation that typically occurs during weight loss, where energy expenditure decreases more than predicted by changes in body mass

Weight Loss In both trials, a marked dose-dependent WL was observed

Popular weight-loss drugs known as GLP-1s could soon become more affordable for Americans

Fatty liver: Can lead to fatty liver disease, which may progress to liver dysfunction, cirrhosis, or require liver transplant

However, Semaglutide remains one of the most established and trusted GLP-1 medicines because of its strong long-term safety and cardiovascular research