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Statistical significance for comparisons between treated and control cell samples was determined by the unpaired t -test using Statistica 10.0 PL software

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However, conservative approaches such as lifestyle modification, dietary control and physical activity are usually unsatisfactory to achieve satisfactory weight reduction in patients with obesity [35-37] Successful obesity management expands beyond weight loss, as it is important to highlight the assessment of the life quality and the prevention of obesity-related comorbidities [38]